There is a clash of cultures and generations within the FBI. But old and young face new kinds of criminal behavior -- crimes unimagined in past decades, and tough to solve now. Four agents-in-training are nearing graduation at the FBI Training Academy in Quantico, Virginia. The Academy and law enforcement in general is in radical flux, and the world in which they will work will be very different from the world of their teachers. The FBI is adjusting its training to pursue justice in an economy besieged by all manner of high-tech crime, and to fit into a world in which psychology and treatment are to replace incarceration and punishment. New forensic biology facilities research is underway into bio-hacking -- the creation or modification of human genes for criminal purposes. Mysterious releases of smallpox and anthrax have killed only single individuals and are not infectious to others; someone has found a way to individually target plagues. The four young agents trace some of the outbreaks to a cadre of freakish high school and college students.